Exercise

Understanding the impact on pathways

Pathways are another useful way to group genes. In this exercise, you will examine the results of a pathway enrichment analysis that looks at peaks that are more pronounced in the primary tumor samples. The object enrich_primary contains the results. This is a list with four entries. Your main interest at this point is in results, a data frame of enrichment results, ordered by significance. It includes the ID and name of the gene sets and the genes associated with peaks that are part of the gene set. Here, genes are reported as Entrez IDs. You can use the database provided by the org.Hs.eg.db package to convert between Entrez IDs and gene symbols. The select() function provides a convenient interface to select entries from the SYMBOL column using the ENTREZID key type.

Instructions

100 XP
  • Examine the top gene sets.
  • Extract the gene IDs for the top ranking set.
  • Split gene IDs into a vector.
  • Convert gene IDs to gene symbols.